Clarke Research Group
The core research theme of our group is the application of modern techniques in mass spectrometry (MS) for the functional and structural characterisation of biological systems. Our research utilises a range of MS-based techniques including : top-down and middle-down fragmentation, ion-mobility mass spectrometry, native mass spectrometry, and hydrogen/deuterium exchange. These MS-based studies are supported by complementary biochemical analysis, chemical biology techniques and structural biology approaches.
12th North American FT MS Conference
Key West, Florida
28 April - 2 May 2019
1st European Top-Down Proteomics Workshop
12-14 Feb 2019
Our latest paper is now available online, published in Nature Communications. 'S-nitrosylation of the zinc finger protein SRG1 regulates plant immunity'. A collaborative project with the Loake group in the School of Biological Sciences.
Our latest paper has just gone online, published in eLife (open access). Read all about our structural and biochemical study of an encapsulated ferritin. Congratulations to all the team in Edinburgh and Newcastle - a real collaborative effort between Marles-Wright, Clarke, and Waldron research groups. See our Publications page for more information.