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Clarke Research Group

The core research theme of our group is the application of modern techniques in mass spectrometry (MS) for the functional and structural characterisation of biological systems. Our research utilises a range of MS-based techniques including : top-down and middle-down fragmentation, ion-mobility mass spectrometry, native mass spectrometry, and hydrogen/deuterium exchange. These MS-based studies are supported by complementary biochemical analysis, chemical biology techniques and structural biology approaches.


BMSS Ambient Ionisation SIG Meeting 2024
Birmingham, UK

1st Feb 2024
72nd American Society of Mass Spectrometry, Annual Conference.
Anaheim Convention Center, Anaheim, California

June 2 - 6, 2024


If you are interested in joining the group as a PhD Student or PostDoc Research Associate then please get in touch

Please contact us for further details.

Read our latest application of Isotope Depletion Mass Spectrometry. 

We combine Isotope Depletion with Native Top-Down MS to investigate the alpha-synuclein dimer interface. 

Read our work on the development of Isotope Depletion Techniques for Protein Mass Spectrometry.



Our recent  paper has been published in Science Advances (open access). Read all about our structural and biochemical study of a bacterial nanocompartment. Congratulations to all the team in Edinburgh and Newcastle - a real collaborative effort between Marles-Wright and Clarke research groups.  See our Publications page for more information. 


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